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KMID : 0869020060090020146
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Journal of Korean Orthopaedic Research Society
2006 Volume.9 No. 2 p.146 ~ p.152
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Physeal Defect Model of Rabbit’s Tibia: Conventional Curettage vs Box Osteotome Method
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Yoo Won-Jun
Cho Tae-Joon
Lee Dong-Yeon
Lee Ki-Seok
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Abstract
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Purpose: In many previous animal studies on cell therapy to the physeal defect, the defect was made by curetting the physeal cartilage with a scalpel, a syringe needle, or a curette. Authors questioned the validity of this method because it may be accompanied by the risk of incomplete removal of physis.
Materials and Methods: Eight-week-old New Zealand White rabbits were used. In the scalpel group (n=32), a physeal defect was made on the medial half of the bilateral proximal tibiae by the conventional curettage method as previously described. In the box osteotome group (n=16), physis and adjoining eiphyseal and metphyseal bone segments were removed with a box osteotome and a motorized burr.
Results: Histological examination showed that, in the scalpel group, incomplete removal of physeal cartilage was observed in 14 of 38 (37%) tibiae sacrificed between Day 1 and 7, while all of the 20 (100%) in the box osteotome group showed complete removal of physeal cartilage.
Conclusion: The results show the high risk of incomplete removal of physeal cartilage with the conventional curettage method. We believe that our method using a box osteotome and a motorized burr is better in terms of ease and validity in creating physeal defect.
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KEYWORD
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Curettage, Box osteotome, Physeal defect, Rabbit
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